STRATEGIES FOR VIRULENCE GENES REGULATION IN Salmonella TYPHIMURIUM: DEVELOPMENT OF ATTENUATED VACCINES

DELGADO, MONICA ALEJANDRA

San Miguel de Tucumán-Tucumán

Conferencia; XII Congreso Argentina de Microbiología General de la Sociedad argentina de Microbiología General; 2017

Sociedad argentina de Microbiología General

Foodborne diseases (FBD) affect the worldwide human health and are among the top five causes ofdeath in children under 5 years. When are caused by bacteria, are usually presented as gastroenteritiswith inflammatory or no inflammatory diarrheas, and in more severe cases produces the individualdeath. The currently strategies used to solve and prevent its diseases acquisition is the vaccine?s treatment,developed with genetically modified microorganisms attenuated in their virulence. In my lab,several S. Typhimurium virulence-attenuated strains have been obtained, some of which are capableto replication into dendritic cells, producing the host immunogenic response, but that are unable toreplicate within macrophages, by which are gradually removed from the host. This makes them excellentcandidates for new vaccines development. My lab?s goals are: i- to conduct a deep and controlledsurvey of pathogens causing FBDs in the NOA region (Shigella, Salmonella and E. coli); ii- characterizethe main immunogenic components present in these isolates, and iii- to develop attenuated and vectorsvaccines for the heterologous antigens expression, as an effective treatment to prevent and combatsuch diseases.