Linfomas en pacientes pediátricos con Sindrome de Inmunodeficiencia Adquirida (SIDA). Presentación de 5 casos

CALCAGNO, L.; DE MATTEO, E; PRECIADO, M. V.; PAOLA ANDREA CHABAY; MAGLIO, S.

Buenos Aires

Congreso; Conferencia Latinoamericana de Patología Pediátrica; 2000

Lymphomas are the most common neoplasms in AIDS patients. The spectrum of lymphoid malignancies includes non- Hodgkin’s lymphomas (NHL), primary lymphoma of the brain (PBL), and Hodgkin’s disease (HD). These lymphomas have a strong association with Epstein-Barr virus (EBV) infection. Methods: Lymphomas from five AIDS patients diagnosed in our hospital during the last decade were studied. Medical histories and the histology were reviewed. Immunohistochemical techniques using the streptavidin-biotin-peroxidase method for CD20, CD3, CD30, CD15, CD45, and LMP1, and in situ hybridization for EBV (EBER) were performed. our hospital during the last decade were studied. Medical histories and the histology were reviewed. Immunohistochemical techniques using the streptavidin-biotin-peroxidase method for CD20, CD3, CD30, CD15, CD45, and LMP1, and in situ hybridization for EBV (EBER) were performed. our hospital during the last decade were studied. Medical histories and the histology were reviewed. Immunohistochemical techniques using the streptavidin-biotin-peroxidase method for CD20, CD3, CD30, CD15, CD45, and LMP1, and in situ hybridization for EBV (EBER) were performed. our hospital during the last decade were studied. Medical histories and the histology were reviewed. Immunohistochemical techniques using the streptavidin-biotin-peroxidase method for CD20, CD3, CD30, CD15, CD45, and LMP1, and in situ hybridization for EBV (EBER) were performed. Lymphomas from five AIDS patients diagnosed in our hospital during the last decade were studied. Medical histories and the histology were reviewed. Immunohistochemical techniques using the streptavidin-biotin-peroxidase method for CD20, CD3, CD30, CD15, CD45, and LMP1, and in situ hybridization for EBV (EBER) were performed. Results: Three patients were boys, two were girls, with ages from 2.6 to 11 years. Primary localization of the tumours were lymph node (3), orbit (1), and central nervous system (1). In the latter patient the diagnosis was made at autopsy. All patients died between 1 and 6 months after diagnosis of the lymphoma. Histologic diagnoses were Burkitt’s lymphoma (2), large cell lymphoma (1), and HD, lymphocyte depletion (1). The NHL from 2.6 to 11 years. Primary localization of the tumours were lymph node (3), orbit (1), and central nervous system (1). In the latter patient the diagnosis was made at autopsy. All patients died between 1 and 6 months after diagnosis of the lymphoma. Histologic diagnoses were Burkitt’s lymphoma (2), large cell lymphoma (1), and HD, lymphocyte depletion (1). The NHL from 2.6 to 11 years. Primary localization of the tumours were lymph node (3), orbit (1), and central nervous system (1). In the latter patient the diagnosis was made at autopsy. All patients died between 1 and 6 months after diagnosis of the lymphoma. Histologic diagnoses were Burkitt’s lymphoma (2), large cell lymphoma (1), and HD, lymphocyte depletion (1). The NHL from 2.6 to 11 years. Primary localization of the tumours were lymph node (3), orbit (1), and central nervous system (1). In the latter patient the diagnosis was made at autopsy. All patients died between 1 and 6 months after diagnosis of the lymphoma. Histologic diagnoses were Burkitt’s lymphoma (2), large cell lymphoma (1), and HD, lymphocyte depletion (1). The NHL Three patients were boys, two were girls, with ages from 2.6 to 11 years. Primary localization of the tumours were lymph node (3), orbit (1), and central nervous system (1). In the latter patient the diagnosis was made at autopsy. All patients died between 1 and 6 months after diagnosis of the lymphoma. Histologic diagnoses were Burkitt’s lymphoma (2), large cell lymphoma (1), and HD, lymphocyte depletion (1). The NHL Pediatric and Developmental Pathology 4, 590–597, 2001 Pediatric and Developmental Pathology © 2001 Society for Pediatric Pathology were of B lymphocytes. Cases in which EBV was searched for (4) were all positive. Conclusions: Our results demonstrate (a) a strong association of AIDS-related lymphomas to EBV and (b) AIDS-related NHL were of B-cell origin of AIDS-related lymphomas to EBV and (b) AIDS-related NHL were of B-cell origin of AIDS-related lymphomas to EBV and (b) AIDS-related NHL were of B-cell origin of AIDS-related lymphomas to EBV and (b) AIDS-related NHL were of B-cell origin Our results demonstrate (a) a strong association of AIDS-related lymphomas to EBV and (b) AIDS-related NHL were of B-cell origin