The interplay between local immune response and Epstein-Barr virus infected tonsillar cells could lead to viral infection control

VISTAROP A; COHEN, M; HUAMAN F; IRAZU L; RODRIGUEZ M; DE MATTEO E; PRECIADO MV; PAOLA ANDREA CHABAY

MEDICAL MICROBIOLOGY AND IMMUNOLOGY

SPRINGER

Lugar: Berlin; Año: 2018

0300-8584

Epstein Barr Virus (EBV) gains access to the host through tonsillar crypts. Our aim was to characterize microenvironment composition around EBV+ cells in tonsils from pediatric carriers, in order to disclose its role on viral pathogenesis. LMP1 expression, assessed by immunohistochemistry (IHC), was used to discriminate EBV+ and ?zones in 41 tonsil biopsies. Three regions were defined: Subepithelial (SE), Interfollicular (IF) and Germinal Center (GC). CD8, GrB, CD68, IL10, Foxp3, PD1, CD56 and CD4 markers were evaluated by IHC; positive cells/100 total cells were counted. CD8+, GrB+, CD68+ and IL10+ cells were prevalent in EBV+ zones at the SE region (p