Role of HLA-DP and HLA-DQ on the protection against chronic hepatitis B virus (HBV) infection and viral clearance in two regions of argentina with dissimilar ancestry genetic background

JULIETA TRINKS; ML HULANIUK, M CAPUTO, T TSUCHIURA, S MARCIANO, L HADDAD, J BLEJER, S BARTOLI, BM AMEIGEIRAS, S FRIAS, C VISTARINI, F HEINRICH, C REMONDEGUI, S CEBALLOS, G ECHENIQUE, M CHARRE SAMMAN, C DAMICO, A ROJAS, A MARTINEZ, E RIDRUEJO, RJ FERNANDEZ; DIEGO FLICHMAN; NISHIDA NAO; TOKUNAGA KATSUSHI; MIZOKAMI MASASHI

Boston

Congreso; 67th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD); 2016

American Association for the Study of Liver Diseases

HBV infection has become a serious problem among NativeAmericans in the Amazon Basin and in other Amazon-relatedecological systems from South America. While HBV ratesare low in the central and metropolitan region of Argentina(MET), the Northwestern region (NWA) exhibits intermediateHBV rates. Unfortunately, the reasons that could explain thisdifference are still unknown. Hence, 1440 Argentines wererecruited and defined into 3 groups: HBV patients (201 fromMET and 200 from NWA) who were HBsAg(+) for more than6 months, HBV resolved individuals (318 from MET and 313from NWA) who were HBsAg(-)/total anti-HBc antibodies(+),and healthy controls (207 from MET and 201 from NWA)who were negative for both markers. Genetic ancestry wasassessed by analysis of bi-parental lineages and ancestry autosomaltyping in all samples. SNPs of HLA-DPA1 (rs3077), HLADPB1(rs9277542), HLA-DQB1 (rs2856718) and HLA-DQB2(rs7453920) were also determined. HBV genotyping was performedby phylogenetic analysis in HBsAg(+) samples. NativeAmerican ancestry prevailed in NWA when compared withMET (p