INVESTIGADORES
RAIGER IUSTMAN Laura Judith
artículos
Título:
Effects of reducing, oxidizing and alkylating agents on early steps of Junin virus multiplication
Autor/es:
L. J. RAIGER IUSTMAN; V. CASTILLA; V. MEICH; S. E. MERSICH
Revista:
ARCHIVES OF VIROLOGY
Editorial:
Springer
Referencias:
Lugar: Wien; Año: 1998 vol. 143 p. 1425 - 1432
ISSN:
0304-8608
Resumen:
The action of reducing, oxidizing and thiol-alkylating agents on early
steps of Junin virus (JV) multiplication in Vero cells was
investigated. The presence of reducing agents during virus adsorption
as well as incubation of viral particles with these compounds before
infection enhanced JV infectivity. On the contrary, the
thiol-alkylating agent 5, 5' dithiobis (2-nitrobenzoic acid) and the
oxidizing compound potassium periodate showed an inhibitory effect,
suggesting that sulfhydryl groups and certain sugar moieties of viral
glycoproteins play an important role in the first steps of JV
infection. Also enzymatic treatment of cell monolayers and addition of
concanavalin A to cultures prior to infection suggest that cellular
glycoproteins are involved in virus attachment.
