MICROSTRUCTURE EFFECT IN NANO CARRIER COPOLYMERS

A. IBORRA; L. M. SALVATIERRA; J. M. GIUSSI; O. A. AZZARONI

San Sebastián

Workshop; International Workshop on Self-Assembly and Hierarchical Materials in Biomedicine; 2018

CIC biomaGUNE SIINN Gobierno Vasco

One of the key points of drug delivery lies in the possibility of encapsulating hydrophobic drugs and thus being able to transport them in physiological media protecting them from the harsh conditions in vivo. Ethylene oxides are frequently used for the formation of potential nanocompartments that allow the circulation of drugs throughout the body. On the other hand, the microstructure and the composition in nanocarrier copolymers has been demonstrated to be crucial in the final properties of materials based in these systems. In this work complete synthesis of copolymers for two condition of reaction based on lauryl methacrylate (LMA) and poly(ethylene glycol) methyl ether methacrylate (PEGMA) was carried out by atom transfer radical copolymerization (ATRP). Fineman-Ross method suggested rLMA > 1 > rPEGMA indicating a random distribution of the monomeric units along the chain copolymer and a tendency towards alternation; evaluated by the compositional ?drift effect? in the thermal and solution properties of the obtained copolymers. The incorporation of a hydrophobic substance (toluene) in the formed micelles was evaluated by DLS and characterized by atomic force microscopy (AFM), diffusion ordered spectroscopy-NMR (DOSY), nuclear Overhauser effect spectroscopy-NMR (NOESY).