El resveratrol como modulador in vivo del daño genómico inducido por radiaciones ionizantes

ELIANA OCOLOTOBICHE; BANEGAS YULIANA; CÓRDOBA ELISA; ALBA M. GÜERCI

Jornada; XXXIII Jornadas Multidiciplinarias de Oncología Instituto Angel Roffo.; 2018

Radiotherapy is an effective tool for cancer control, but side effects on normal tissue limit its therapeutic effectiveness. Thus, the search for agents that may allow the use of high doses of radiation but exerting a differential protection to healthy tissue is of current concern. Resveratrol (3, 5, 4´-trihydroxy-trans-stilbene) (RVS) is a polyphenol with pleiotropic benefits for health due to its antioxidant and anti-inflammatory properties. Recent findings suggest that RVS could be promising in the fight against cancer since it inhibits the growth of tumor cells and optimizes radiotherapy. However, evidence in rodents and human beings is inconsistent. The aim of this study was to evaluate the radiomodulatory capacity of RSV in irradiated human peripheral blood lymphocytes from healthy women undergoing in vivo RVS treatment. Genotoxic damage assessment by the comet assay determined that 50 mg/day doses of RVS used as a dietary supplement had radioprotective properties, without exerting cytotoxic effect. Therefore, its potential utility to optimize the radiotherapeutic ratio in cancer radiant treatments should be considered.