Neuroendocrine-Immunological Interactions in Health and Disease.

CARVALHO V. F.; PÉREZ A. R. ; MAYA-MONTEIRO C. M.

Frontiers Media SA

Lugar: Laussanne; Año: 2021 p. 303

978-2-88971-525-1

It is known that endogenous hypercortisolism or exposure toexogenous glucocorticoids can lead to Cushing?s syndrome. Liuet al. report on a rare case of an ectopic ACTH-dependentCushing?s syndrome and proposed a mechanism for this uniqueclinical phenotype. Despite the adverse effects that sustainedhypercortisolism may cause, the chronic use of corticosteroids totreat inflammatory diseases is widely accepted in clinical settings.As reported here, Ferreira et al. revealed a promising use offlunisolide as a pharmacological treatment for silicosis. Anotherimportant neuro-endocrine circuit, essential for dealing withstress, is the sympatho-adrenal system. Pilipovic et al.summarized the data, pointing to an immunopathogenic rolefor the sympathoadrenal axis in the pathogenesis of experimentalautoimmune encephalomyelitis and multiple sclerosis. (Continue....)DOI: 10.3389/978-2-88971-525-1