Metabolic and immunoendocrine profile in subjects with chronic chagas disease

GONZALEZ F.; VILLAR S.; LEIVA R.; LIOI S.; MARQUEZ J.; SCAGLIONE L.; BELOSCAR J.; BOTTASSO O.; PEREZ AR.

Bs As

Congreso; 1st LASID SAI FAIC Meeting; 2015

Sociedad Argentina de Inmunologia

The metabolic status of an individual is influenced by endocrine and immunological factors. Chronic Chagas disease (ChC) is an infectious illness caused by the parasite Trypanosoma cruzi, which could result in cardiomyopathy, a marked proinflammatory profile and a dysbalance in the DHEA/cortisol ratio. Recently, adipose tissue has been identified as target of T. cruzi infection, possibly influencing the energetic metabolism and the severity of disease. The aim of this study was to investigate whether the levels of circulating factors involved in the inmunoendocrine and metabolic response in ChC patients are related to the severity of heart disease. For this, 109 patients and 24 healthy individuals (Co) were recruited. ChC subjects were evaluated by ECG thoracic X-ray Rx and classified as: Asymptomatic (without heart disease, Asy, n =46) or with cardiomyopathy (c/C, n =63), and subclassified as mild/moderate (LM, n = 31) or severe (Sev, n =32). Serum adiponectin, leptin, IL-6, insulin, body mass index (BMI) were evaluated. The data obtained showed that Sev had increased BMI and IL-6 compared to Co (p