Dysregulated network of immune, endocrine and metabolic markers is associated to more severe human chronic Chagas cardiomyopathy

GONZALEZ FLORENCIA ; VILLAR SILVINA; D´ATTILIO LUCIANO; LEIVA RODOLFO; MARQUEZ JULIA; LIOI SUSANA; BELOSCAR JUAN; BOTTASSO OSCAR; PEREZ ANA ROSA

NEUROIMMUNOMODULATION.

KARGER

Lugar: Basel; Año: 2018

1021-7401

Trypanosoma cruzi infected individuals develop chronic Chagas cardiomyopathy (CCC), whose pathogenesis involves immune mechanisms. Recently an association between immune and metabolic alteration has been proposed. Here, we investigated the immuno-metabolic response in chagasic patients and their possible influence on CCC pathogenesis.Accordingly, T. cruzi-seropositive (asymptomatic or with CCC) and sero-negative individuals were studied. Serum TNF-α, IL-6, adipocytokines and the expression of their receptors in PBMC were evaluated, together other factors that influence immune response. CCC patients showed major metabolic and hormonal abnormalities, in parallel with increased IL-6 and leptin serum levels. TNF-Rs, leptin and adiponectin receptors (ObR and Adipo-Rs respectively) and PPAR-γ expression in PBMCs from CCC patients was compatible with a counteracting response to an unfavourable immune-metabolic profile. These results suggested that persistently increased levels of immune-metabolic pro-inflammatory mediators together with an adverse endocrine anti-inflammatory response that seem to display CCC individuals, may be contributing to the underlying mechanism that sustains myocardial tissue damage.