THE CHRONIC TOXICITY OF PANI-Nps TO THE LARVAE STAGE OF RHINELLA ARENARUM

LUIS E. IBARRA; SILVESTRE BONGIOVANNI; CÉSAR A. BARBERO; VIVIANA A. RIVAROLA; MABEL L. BERTUZZI; EDITH I. YSLAS

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

AMER SCIENTIFIC PUBLISHERS

Año: 2016 vol. 16 p. 7983 - 7988

1533-4880

The interaction between live organisms and nanosized materials has become a current focus intoxicology. The aim of this study was to establish the chronic effects of PANI-Nps in different dispersanton Rhinella arenarum toad larvae. We propose the use of organism?s models to understand thetoxic mechanistic modes of action that could occur by exposure to Nps. AMPHITOX is proving to bea quick, cheap, and facile model to conservatively assess toxicity of nanomaterials. The toxicity ofboth: PANI-Np1 (PANI-Np dispersed in PVP) and PANI-Np2 (PANI-Np dispersed in PVP+PNIPAM)was time- and concentration-dependent. The range of concentrations used were 182?980 mg/L forPANI-Np1 or 250?1000 mg/L for PANI-Np2 and the larval stage used was S.25 (closed branchiae).PANI-Np2 was more toxic than PANI-Np1 based on the chronic toxicity results. At stage S.25, noalterations in the larvae skin were observed while nanoparticle precipitations were detected intothe digestive tract; suggesting that PANI nanoparticles are probably unable to enter through theoral route.