Synthesis and Biological Evaluation of Methoxyphenyl Porphyrin Derivatives as Potential Photodynamic Agents

M. ELISA MILANESIO; FLAVIA S. MORÁN; E. I. YSLAS; M. GABRIELA ÁLVAREZ; VIVIANA RIVAROLA; EDGARDO N. DURANTINI.

BIOORGANIC & MEDICINAL CHEMISTRY.

PERGAMON-ELSEVIER SCIENCE LTD

Año: 2001 vol. 9 p. 1943 - 1949

0968-0896

A new meso-2,4,6-trimethoxyphenyl porphyrin covalently linked to a 20,60-dinitro-40-trifluoromethylphenyl group by an amine bond 5 and its metal complex with Cd(II) 6 was prepared. The photodynamicac tivities of 5 and 6 were evaluated in vitro on Hep-2 cells. A considerable increase in the photocytotoxic effect was found for 6, which has higher singlet molecular oxygen, O2(1g), production.