Non-hepatosplenic gamma-delta T-cell lymphoma with initial testicular localization.

SCOLNIK MP; BURGOS RA; PAZ A; BARÉ P; PALACIOS MF; SOLER MD; WENREITER M; ARDAIZ MC; BAYO MC; SASOT A; HUBERMAN A; DE BRACCO MM

AMERICAN JOURNAL OF HEMATOLOGY

Año: 2000 p. 260 - 262

0361-8609

We report here a case of nonhepatosplenic gammadelta T-cell lymphoma with undescribed initial localization in testis, without hepatosplenomegaly or adenopathies, and subsequent development in the maxillary sinus. The maxillar mass biopsy revealed a T-cell infiltration, and its immunologic characterization by flow cytometry showed a gammadelta T-cell phenotype (CD45+, CD3+, CD2+, TCR gammadelta+), without expression of CD7, CD5, CD1a, TdT, CD4, CD8, TCR alphabeta, or NK antigens (CD16, CD56, and CD57). Clonal gamma-chain gene rearrangement by polymerase chain reaction (PCR) was detected in testicular and maxillar biopsies. Epstein-Barr virus type 1 (EBV) sequences were detected by molecular biology in the biopsy material, suggesting that this oncogenic virus may play a role in the genesis of the clonal expansion of gammadelta T-cells. The patient was initially treated with standard chemotherapeutic protocols, with poor response and aggressive course.