Controlled HIV-HCV Viremia and Immune-Reconstitution are Associated with Slow Progression of Liver Disease in Co-infected Hemophilic Patients After 30 Years of Follow-Up

MONZANI CECILIA; BADANO MARÍA NOEL; ALOISI NATALIA; GUALTIERI A; CORTI MARCELO; PARODI CECILIA; DE TEZANOS PINTO M; NEME DANIELA; PRIMIANI LAURA; BRACCO MARÍA MARTA; CHUIT ROBERTO; BARÉ PATRICIA

Japanese Journal of Gastroenterology and Hepatology

Kurume University Hospital,

Lugar: Niigata; Año: 2020 vol. 4 p. 1 - 7

2435-1210

1.1. Introduction and aim: Controversial results have been reported about the progression of liver disease in HIV-HCV coinfected populations. The purpose of this study is to assess long-term liver disease progression in a group of coinfected patients with hemophilia.1.2. Materials and Methods: From 1995 to 2015, liver disease was assessed through enzyme levels, platelet counts, Hepatitis C and HIV viral loads (VL), and CD4+T cell counts. Evolution of the APRI liver index was used to estimate hepatic disease (APRI > 1.0 indicating severe fibrosis).1.3. Results: 2005-2015 proportional liver-related mortality was below 17% while AIDS and other causes including hemorrhagic events reached 42% each. APRI index >1.0 was found in 3 of 32 (9%) patients alive, showing significant liver disease after more than 30 years of infection. Analyzing the evolution of liver disease markers, liver enzymes increased significantly only in those patients with detectable HIV and /or HCV VL (for AST and ALT, p