Exposure to growth hormone is associated with hepatic up-regulation of cPLA2 and COX.

PIAZZA VG; MATZKIN ME ; CICCONI NS ; MUIA NV ; VALQUINTA S; MCCALLUM GJ ; MICUCCI GP; FREUND T ; ZOTTA E; GONZÁLEZ L ; FRUNGIERI MB ; FANG Y ; BARTKE A ; SOTELO AI ; MIQUET JG

MOLECULAR AND CELLULAR ENDOCRINOLOGY.

ELSEVIER IRELAND LTD

Lugar: Amsterdam; Año: 2020

0303-7207

Continuously elevated levels of growth hormone (GH) during life in mice are associated with hepatomegaly due to hepatocytes hypertrophy and hyperplasia, chronic liver inflammation, elevated levels of arachidonic acid (AA) at young ages and liver tumors development at old ages. In this work, the hepatic expression of enzymes involved in AA metabolism, cPLA2α, COX1 and COX2 enzymes, was evaluated in young and old GH-transgenic mice. Mice overexpressing GH exhibited higher hepatic expression of cPLA2α, COX1 and COX2 in comparison to controls at young and old ages and in both sexes. In old mice, when tumoral and non-tumoral tissue were compared, elevated expression of COX2 was observed in tumors. In contrast, exposure to continuous lower levels of hormone for a short period affected only COX1 expression in males. Considering the role of inflammation during liver tumorigenesis, these findings support a role of alterations in AA metabolism in GH-driven liver tumorigenesis.