The tyramine receptor TYRA-3 is involved in the neural coordination of oxidative stress response in the model organism C.elegans.

VEUTHEY, TANIA; DE ROSA MARÍA JOSÉ; RAYES DIEGO

Mar del Plata

Congreso; XXX Reunión Anual Sociedad Argentina de Investigación en Neurociencias; 2015

Sociedad Argentina De Investigación en Neurociencias

 Thenervous system plays a pivotal role in the coordination of systemic stressresponse in multicellular organism. However, the molecular and cellular basisof this modulation are poorly understood. Oxidative stress constitutes one ofthe most complex forms of systemic stress and play a major role in thepathogenesis of conditions such as diabetes, cancer and neurodegenerativedisorders. In addition, strong evidences have linked increased oxidative stresswith aging. Our previous results have related the neural tyraminergic signaling,the invertebrate counterpart for adrenergic transmission,  and the systemic response to starvation andthermal stress in C. elegans. Byanalyzing the survival  of different C. elegans mutant strains, we here  evaluated the role of this aminergicsignaling in the iron-induced oxidative stress response. Our results show thatinhibition of tyramine release in the nervous system is essential for mountingan appropriate systemic response to oxidative stress. Moreover we identifiedthe GPCR TYRA-3 as the receptor involved in this neural modulation. We are nowevaluating both, the specific cells where TYRA-3 expression is required as wellas the molecular pathways underlying this regulation. Our work will contributeto identify cellular and molecular mechanisms involved in neuronal coordinationof systemic stress response, leading to a better understanding of theintegration between stress sensory perception and the response in non-neuronalcells.