Predicting episodic memory performance using different biomarkers: Results from Argentina-Alzheimer’s disease neuroimaging initiative

RUSSO, MARÍA JULIETA; COHEN, GABRIELA; MENDEZ, PATRICIO CHREM; CAMPOS, JORGE; NAHAS, FEDERICO E.; SURACE, EZEQUIEL I.; VAZQUEZ, SILVIA; GUSTAFSON, DEBORAH; GUINJOAN, SALVADOR; ALLEGRI, RICARDO F.; SEVLEVER, GUSTAVO

Neuropsychiatric Disease and Treatment

Dove Medical Press Ltd.

Año: 2016 vol. 12 p. 2199 - 2206

1176-6328

Purpose: Argentina-Alzheimer?s Disease Neuroimaging Initiative (Arg-ADNI) is the first ADNI study to be performed in Latin America at a medical center with the appropriate infrastructure. Our objective was to describe baseline characteristics and to examine whether biomarkers related to Alzheimer?s disease (AD) physiopathology were associated with worse memory performance. Patients and methods: Fifteen controls and 28 mild cognitive impairment and 13 AD dementia subjects were included. For Arg-ADNI, all biomarker parameters and neuropsychological tests of ADNI-II were adopted. Results of positron emission tomography (PET) with fluorodeoxyglucose and11C-Pittsburgh compound-B (PIB-PET) were available from all participants. Cerebrospinal fluid biomarker results were available from 39 subjects. Results: A total of 56 participants were included and underwent baseline evaluation. The three groups were similar with respect to years of education and sex, and they differed in age (F=5.10, P=0.01). Mean scores for the baseline measurements of the neuropsychological evaluation differed significantly among the three groups at P0.1). Baseline amyloid deposition and left hippocampal volume separated the three diagnostic groups and correlated with the memory performance (P