INVESTIGADORES
SURACE Ezequiel Ignacio
artículos
Título:
Generation of a human induced pluripotent stem cell line (INEUi001-A) from an amyotrophic lateral sclerosis/frontotemporal dementia patient with a C9ORF72 G4C2 genotype of <2 (GGGGCCG) and 10 repeats
Autor/es:
NIEVAS, MICAELA; ROMORINI, LEONARDO; ISAJA, LUCIANA; CLAS, GIULIA S.; RODRÍGUEZ-VARELA, SOLEDAD; MUCCI, SOFÍA; ITZCOVICH, TATIANA; DE AMBROSI, BRUNO; SCASSA, MARÍA E.; SEVLEVER, GUSTAVO E.; SURACE, EZEQUIEL I.; MARAZITA, MARIELA C.
Revista:
STEM CELL RESEARCH
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2023 vol. 69
ISSN:
1873-5061
Resumen:
Human induced pluripotent stem cell (hiPSC) line INEUi001-A was reprogrammed from peripheral blood mononuclear cells (PBMC) using the lentiviral-hSTEMCCA-loxP vector. PBMCs were obtained from a 75- year-old female ALS/FTD disease patient carrying a heterozygous deletion within the C9ORF72 hexanucleotide repeat region resulting in a GGGGCCG sequence (∼1.16 repeats). C9ORF72 genotype was maintained and stemness and pluripotency confirmed in INEUi001-A hiPSC line.
