Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas (Rhea americana albescens).a preliminary study

DE LUCAS, JJ;; RODRIGUEZ,C;; MARTELLA, MB;; LABAQUE, MC.;; NAVARRO, JL;; SAN ANDRES, MJ

RESEARCH IN VETERINARY SCIENCE

ELSEVIER SCIENCE

Lugar: SASKATOON; Año: 2005 vol. 78 p. 265 - 267

0034-5288

The pharmacokinetic behaviour of enro .oxacin (ENR)and its active metabolite cipro .oxacin (CIP)were determined in six greater rheas following a single intravenous (i.v.) dose of 15 mg/kg bw. Plasma concentrations of ENR and CIP were simultaneously determined by a HPLC/u.v.method. Following i.v. administration, the plasma drug concentrations were best .tted by an open two-compartment model with a rapid distribution phase. The high volume of distribution (V ss =5.01 L/Kg) suggests good tissue penetration. ENR presents a high clearance (3.95 L/kg h) explaining the low AUC values (3.57 mg h/L) and a short permanence (t1/2 b =2.66 h and MRT =1.23 h). Cipro oxacin comprised 14%of the total uoroquinolone (ENR +CIP).