Increased IL-17 plasma levels associated with more activated circulating CD4+ lymphocytes in patients with mood disorders

TIFNER, VERA; ARENA, ÁNGELES ROMINA; GRENDAS, LEANDRO NICOLÁS; PENNA MELINA B; HUNTER FERNANDO; OLAVIAGA A; PROKOPEZ C.; ARMESTO, ARNALDO; ALVAREZ ROMINA; CHIAPELLA LUCIANA; CARRERA SILVA EUGENIO A*; DARAY, FEDERICO M.*; ERRASTI, ANDREA EMILSE *

Mar del Plata

Congreso; Reunión Conjunta SAIC-SAI-SAFIS 2022; 2022

During the last years, emerging evidence associated Mood Disor- ders (MD) with increased inflammatory status suggesting a role for the innate and adaptive immune system in the developing and main- taining of MD. This study is part of a larger ongoing observational, cross-sectional study and aimed to determine the activation status of immune circulating cells in patients with MD coursing a clinical episode of active depression (AD) or during no clinically active de- pression (NAD). The specific aim of the present work is to answer if MD patients show a differential immune T cell profile analyzing the frequency of CD4+ and CD8+ T cells, the activation status of those CD4+ lymphocytes and their associated cytokines profiling. Patients were evaluated by psychiatrists using the International Psychiatry Interview MINI to diagnose MD and the Hamilton Depression Rat- ing Scale (HADRS) to define AD (N=21) and NAD status (N=21). MD sample was 26% male and 74% female with 18-55 year age range and matched with a healthy control group (HC) by age and gender (N=23). Blood samples were obtained and directly stained and analyzed by flow cytometry. Additionally, a panel of 16 plasma cytokines was measured. IRB approved the study, and each partic- ipant gives the written consent. Our results show that AD patients have an increased CD4/CD8 ratio (2.57) vs. NAD (1.98) and HC (1.99) and increased frequencies of CD3+CD4+CD69+ and CD3+C- D4+PD1+ circulating lymphocytes compared with patients with NAD (p