IEGEBA   24053
INSTITUTO DE ECOLOGIA, GENETICA Y EVOLUCION DE BUENOS AIRES
Unidad Ejecutora - UE
artículos
Título:
Evolutionary Genomics of Genes involved in Olfactory Behavior in the Drosophila melanogaster Species Group
Autor/es:
LAVAGNINO, N. J.; SERRA, F.; ARBIZA., L.; DOPAZO, H.; HASSON, E.
Revista:
EVOLUTIONARY BIOINFORMATICS
Editorial:
BIOINFORMATICS INST
Referencias:
Lugar: Albany; Año: 2012 vol. 8 p. 89 - 104
ISSN:
1176-9343
Resumen:
Previous
comparative genomic studies of genes involved in olfactory behavior in
Drosophila focused only on particular gene families such as odorant receptor
and/or odorant binding proteins. However, olfactory behavior has a complex
genetic architecture that is orchestrated by many interacting genes. In this
paper, we present a comparative genomic study of olfactory behavior in Drosophila
including an extended set of genes known to affect olfactory behavior. We took
advantage of the recent burst of whole genome sequences and the development of
powerful statistical tools to analyze genomic data and test evolutionary and
functional hypotheses of olfactory genes in the six species of the Drosophila
melanogaster species group for which whole genome sequences are available. Our
study reveals widespread purifying selection and limited incidence of positive
selection on olfactory genes. We show that the pace of evolution of olfactory
genes is mostly independent of the life cycle stage, and of the number of life cycle
stages, in which they participate in olfaction. However, we detected a
relationship between evolutionary rates and the position that the gene products
occupy in the olfactory system, genes occupying central positions tend to be
more constrained than peripheral genes. Finally, we demonstrate that
specialization to one host does not seem to be associated with bursts of
adaptive evolution in olfactory genes in D. sechellia and D. erecta, the two specialists
species analyzed, but rather different lineages have idiosyncratic evolutionary
histories in which both historical and ecological factors have been involved.