Evidence of autophagy dysregulation on microglial cells in the context of Alzheimer?s disease using in vitro and in vivo models

POMILIO C; ALAIMO A; GOROJOD R. M.; VINUESA A; PRESA J; BENTIVEGNA M; PORTE ALCON S; BEAUQUIS J; BONIFACINO JS; KOTLER ML; SARAVIA F

Ciudad Autonoma de Buenos Aires

Jornada; Jornadas Interdisciplinarias de Química Biológica; 2017

Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires

Alzheimer disease (AD) is the principal cause of dementia in the elderly. A recognized hallmark of AD is the aggregation of Amyloid-beta peptides (Ab) into senile plaques, frequently surrounded by hypertrophied glial cells. We studied microglial alterations in the hippocampus of PDAPP mice, a well-established transgenic model of AD. Before detection of amyloid deposits in the brain, we found an early increase in the Iba1+ soma related area and activation score (p