Evidence of autophagy dysregulation on microglial cells in the context of Alzheimer?s disease using in vitro and in vivo models

POMILIO C; ALAIMO A; GOROJOD R.; VINUESA A; PRESA J; BENTIVEGNA M; PORTE ALCON S; BEAUQUIS J; BONIFACINO JS; KOTLER ML; SARAVIA F

Polo Científico y Tecnológico, Buenos Aires, Argentina

Encuentro; The role of glial cells in health and disease of the Nervous System: Clinical and Basic Science walking together; 2017

IBRO, ISN

Alzheimer?s disease (AD) is the principal cause of dementia in the elderly. A recognized hallmark of AD is the aggregation of Amyloid-β peptides (Aβ) into senile plaques, frequently surrounded by hypertrophied glial cells. We studied microglial alterations in the hippocampus of PDAPP mice, a well-established transgenic model of AD. Before detection of amyloid deposits in the brain, we found an early increase in the Iba1+ soma related area and activation score (p