KIR, NK and T alterations in chronic HCV and his relevance at clinic

A. PODHORZER; A. MACHICOTE; S. BELEN; S. MARCIANO; S. PAZ; O. GALDAME; L. FAINBOIM; G. PODESTÁ; M. DIRCHWOLF; S. MONTAL; G. THEILER; H. FAIBOIM

Congreso; LXIV Reunión Científica Anual de la Sociedad Argentina de Inmunología; 2016

Patients carrying KIR2DL3 and his ligand in homozygosis have better response to an acute HCV infection. However there are few studies of the role of KIRs in chronic HCV infection.We aim to analyze KIR gen frequency and KIR expression on NK bright, NKdim, from peripheral blood (PB) and from the liver of HCV patients and healthy donors (HD).Expression of KIR receptors were analyzed by flow cytometry on PB of HD (N=63) HCV (N=33) , liver perfusion from HD (N=36) and HCV (N=6). KIR, KIR2DS4 alleles and HLA typing was made by PCR-SSOP technique. In comparison with healthy donors, chronic HCV patients showed an increased frequency of the functional form of the gene KIR2DS4 (KIR2DS4fl; 0.52 vs. 0.42,p