Levels of Bone Turnover in Saliva Correlated with Antirresortive Treatment: Experimental Study

PELLEGRINI, GRETEL GISELA; AVENDAÑO, MARIA EUGENIA; ZENI CORONEL, ESTEFANIA MAGALI; ZENI, SUSANA NOEMI; GONZALEZ CHAVES, MACARENA; BONANNO, MARINA SOLEDAD

Austin Journal of Dentistry

Austin Publishing Group

Año: 2020

Background: Bone turnover markers are useful to evaluate bone loss and monitor anticatabolic treatments in a short period. The effectiveness of saliva to reflect changes in bone turnover markers during the early administration of different doses of olpadronate (POD) (4 mg or 8 mg/100 g body weight), immediately after Ovariectomy (OVX), was evaluated.Material and Methods: Adult rats (n=10/group) were divided and treated as follows for 45 days: SHAM+Vh; OVX+Vh; OVX+4OPD and OVX+8OPD. To validate the model, Proximal Tibia Bone Mineral Density (PTBMD) change between the beginning and the end of the study. Blood and saliva were collected post-surgery (t=0; t=10; t=20; t=45).Results: PTBMD decrease in OVX+Vh was partially prevented by 4OPD and avoided by 8OPD. Salivary and serum β-CrossLaps (CTX) in SHAM+Vh remained without changes and increased in OVX+Vh (p