Effect of denosumab on bone mineral density and markers of bone turnover among postmenopausal women with osteoporosis.

SÁNCHEZ A ; COSTANZO PR ; OLIVERI B; MAFFEI L; LARROUDÉ MS; ULLA MR; BRANCE ML; BRUN LR; SALERNI H; GONZÁLEZ D; BAGUR A; ZANCHETTA MB; FARÍAS V; PREMROU V; MANSUR JL; SARLI MA; REY P; PAVLOVE MM; KARLSBRUM S; SÁNCHEZ A ; COSTANZO PR ; OLIVERI B; MAFFEI L; SALERNI H; LARROUDÉ MS; BAGUR A; ULLA MR; FARÍAS V; BRANCE ML; MANSUR JL; REY P; KARLSBRUM S; BRUN LR; GONZÁLEZ D; ZANCHETTA MB; PREMROU V; SARLI MA; PAVLOVE MM

Journal of Osteoporosis

Hindawi Publishing Corporation

Año: 2016

2090-8059

The aim of this study was to evaluate the effect of denosumab (Dmab) on bone mineral density (BMD) and bone turnover markers after 1 year of treatment. Additionally, the effect of Dmab in bisphosphonate-naïve patients (BP-naïve) compared to patients previously treated with bisphosphonates (BP-prior) was analyzed. This retrospective study included 425 postmenopausal women treated with Dmab for 1 year in clinical practice conditions in specialized centers from Argentina. Participants were also divided according to previous bisphosphonate treatment into BP-naïve and BP-prior. A control group of patients treated with BP not switched to Dmab matched by sex, age, and body mass index was used. Data are expressed as mean ± SEM. After 1 year of treatment with Dmab the bone formation markers total alkaline phosphatase and osteocalcin were significantly decreased (23.36% and 43.97%, resp.), as was the bone resorption marker s-CTX (69.61%). Significant increases in BMD were observed at the lumbar spine, femoral neck, and total hip without differences between BP-naïve and BP-prior. A better BMD response was found in BP-prior group compared with BP treated patients not switched to Dmab. Conclusion. Dmab treatment increased BMD and decreased bone turnover markers in the whole group, with similar response in BP-naïve and BP-prior patients. A better BMD response in BP-prior patients versus BP treated patients not switched to Dmab was observed.