Synergized pediculicide lotions for the control of permethrin resistant head lice (Pediculus humanus capitis (Phthiraptera: Pediculicidae)

VASSENA C. V; TOLOZA A.; MOUGAGURE CUETO G. ; PICOLLO M. I.

Salt Lake City, Utah

Congreso; ICP5. Fifth International Conference on Phthiraptera; 2014

International Society of Phthirapterists

Infestation caused by Pediculus humanus capitís is one of the most important infestations that occur worldwide and infest millions of children and adults every year, especially after the detection of head lice strains that are resistant to the insecticides available in the market. In Argentina, field populations of the head louse have developed resistance to permethrin and other pyrethroids. The resistance in P. h. capítís is a phenomenon of great concern because of the lack of novel insecticides introduced into the market as new safe products for chemical control of head lice.The aim of this work was the development of a lotion containing ivermectin and an alcohol coadjuvant to improve biological effect. We investigated the adulticidal and ovicidal activity of Ivermectin and spinosad and experimental lotions based on this insecticide against permethrin-resistant head lice.We test different combination of actives with different aliphatic alcohols as synergists.The effectiveness of experimental lotions was evaluated by the immersion method.The Lethal Concentration 50% showed that the lotions with ivermectin and spinosad are more effective than those with permethrin on adults but ivermectin was better than spinosad on nits. The modification of pediculicidal formulations to enhance insecticide activity has shown to be one good strategy to optimize the effectiveness of the available products indicating that are a good alternative for commercial head lice products.