UNIDEF 23986
UNIDAD DE INVESTIGACION Y DESARROLLO ESTRATEGICO PARA LA DEFENSA
Unidad Ejecutora - UE
artículos
Título:
Benznidazole levels in blood vary with age in rats
Autor/es:
BULFFER, R.F.; CASTRO JA; FANELL SL
Revista:
MEMóRIAS DO INSTITUTO OSWALDO CRUZ.
Editorial:
FUNDACO OSWALDO CRUZ
Referencias:
Lugar: Sao Paulo; Año: 2011
ISSN:
0074-0276
Resumen:
Benznidazole (Bz) exhibits toxic side effects in animal studies and clinical use. Reductive metabolism of Bz in liver microsomes modulates the duration of its chemotherapeutic effect and its toxicity. The rate of this metabolism depends on age and is less intense in newborns and youngsters than in adults. In the present study, we determined Bz blood levels in rats of different ages that received Bz intragastrically (100 mg/kg). We developed and validated a high-pressure liquid chromatography with UV detector method for determination of Bz levels in whole blood. Bz levels were significantly higher and persisted for longer periods of time in the blood of young rats when compared to that of adult animals.
