Pentacationic chlorine as potential antimicrobial agent.

FERREYRA D.D.; MILANESIO M.E.; DURANTINI E.N.

Conferencia; CLAFQO-13, 13th Latin American Conference on Physical Organic Chemistry; 2015

Photodynamic inactivation (PDI)is an efficient approach against microorganisms and can be used as analternative treatment for microbial infections. This method is based on the irradiationof a photosensitizer (PS), which is accumulated in microbial cells. In thepresence of oxygen, reactive oxygen species are produced causing lethal damageto the microorganisms. Chlorins are second generation PSs and its core has onereduced pyrrole unit, which gives it a strong absorption in the red spectralregion (650?800 nm). This feature makes these compounds ideal PSs for thetreatment of deeper skin infections. In this work, chlorin TPCF20 wassynthetized from 5,10,15,20-tetrakis(perfluorophenyl) porphyrin (TPPF20).