Mechanistic studies on the photodynamic activity mediated by a porphyrin-fullerene C60 dyads on Staphylococcus aureus

M. BELEN BALLATORE, MARIANA B. SPESIA, M. ELISA MILANESIO AND EDGARDO N. DURANTINI

Congreso; 16th International Congress on Photobiology; 2014

Porphyrin derivatives have shown great potential for the photodinamic inactivation (PDI) of microorganisms. An interesting alternative for new compounds to be evaluated as phototherapeutic agents are dyads formed by porphyrins covalently linked to fullerene C60. These dyads present higher capacity to form photoinduced charge-separated state and the electron transfer process competes with the production of singlet molecular oxygen, O2(1g) [3]. In PDI, two photoprocesses can be mainly involved after activation of the photosensitizer. In the type I pathway, the photosensitizer interacts with substrates to produce free radicals, while in the type II mechanism, O2(1g) is produced by energy transfer from the photosensitizer.In the present work, the photodynamic activity of TCP-C60 and TCP-C604+ dyads was evaluated under different conditions.