Antifungal photodynamic activity of porphyrins derivatives bearing aminopropoxy groups

EZEQUIEL D. QUIROGA, S. JIMENA MORA, M. GABRIELA ÁLVAREZ, M. ELISA MILANESIO, EDGARDO N. DURANTINI

Córdoba

Encuentro; XI Encuentro Latinoamericano de Fotoquímica y Fotobiología; 2012

Antimicrobial resistance is a growing problem that complicates the treatment of important nosocomial and community-acquired infections. In the last years, resistance of Candida albicans is increasing against traditional antifungal azole derivatives. Hence, it is necessary to develop alternative therapies for the treatment of candidiasis. A promising modality is photodynamic inactivation (PDI) of microorganisms, which uses a combination of light, a photosensitizer and oxygen to achieve a cytotoxic effect in the cells. In the PDI process, the photosensitizer excited reacts with molecular oxygen, generating highly reactive oxygen species that promote death of microorganism. In this study the photodynamic activity of 5,10,15,20-tetrakis [4-(3-N,N-dimethylaminopropoxy)phenyl]porphyrin (TAPP) and 5,10,15,20-tetrakis [4-(3-N,N,N-trimethylamine propoxy)phenyl]porphyrin (TAPP4+) were compared in presence of fluconazole on Candida albicans.