Effect of testosterone on the activity of inflammatory cells

AMADO A QUINTAR; CAROLINA LEIMGRUBER; NAHUEL PEINETTI; CRISTINA A MALDONADO

Congreso; 15th International Congress of Immunology (ICI); 2013

Immunomodulation by sex hormones have both physiological and pathological implications in several processes. However, the role of androgens in controlling the inflammatory response is just begun to be dissected. Our initial goal was to analyze the influence of testosterone on prostatic inflammation. Wistar rats were castrated and treated with vehicle(C) or testosterone at 0.75mg/rat/day(C+T) or 2.5mg/rat/day(C+TT) and then infected with 106CFU E. coli. At 2d postinfection, C+TT exhibited greater neutrophil invasion and lower levels of TLR4 and βdefensin1 in the prostate compared to C (ANOVAp