Traditional Dietary Pattern Increases Risk of Prostate Cancer in Argentina: Results of a Multilevel Modeling and Bias Analysis from a Case-Control Study

NICLIS, CAMILA.; ROMÁN, MARÍA DOLORES.; OSELLA, ALBERTO; EYNARD, ALDO RENATO; DÍAZ, MARÍA DEL PILAR

Journal of Cancer Epidemiology

Hindawi Publishing Corporation

Lugar: New York; Año: 2015 vol. 2015 p. 1 - 11

1687-8558

There is increasing evidence that dietary habits play a role in prostate cancer (PC) occurrence. Argentinean cancer risk studiesrequire additional attention because of the singular dietary pattern of this population. A case-control study (147 PC cases, 300controls) was conducted in C´ordoba (Argentina) throughout 2008?2013. A principal component factor analysis was performedto identify dietary patterns. A mixed logistic regression model was applied, taking into account family history of cancer. Possiblebias was evaluated by probabilistic bias analysis. Four dietary patterns were identified: Traditional (fatty red meats, offal, processedmeat, starchy vegetables, added sugars and sweets, candies, fats, and vegetable oils), Prudent (nonstarchy vegetables, whole grains),Carbohydrate (sodas/juices and bakery products), and Cheese (cheeses).High adherence to the Traditional (OR 2.82, 95%CI: 1.569?5.099) andCarbohydrate Patterns (OR 2.14, 95%CI: 1.470?3.128) showed a promoting effect for PC,whereas the Prudent andCheesePatterns were independent factors. PC occurrence was also associated with family history of PC. Bias adjusted ORs indicate thatthe validity of the present study is acceptable. High adherence to characteristic Argentinean dietary patterns was associated withincreased PC risk. Our results incorporate original contributions to knowledge about scenarios in South American dietary patternsand PC occurrenc