INICSA   23916
INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Unidad Ejecutora - UE
artículos
Título:
Synergistic Antitumor Effects of Melatonin and Pufas from Walnut Seeds in a Murine Mammary Adenocarcinoma Model
Autor/es:
GARCIA CP, LAMARQUE AL, COMBA A, BERRA MA, SILVA RA, LABUCKAS DO, , DAS UN, EYNARD AR, PASQUALINI ME
Revista:
NUTRITION
Editorial:
ELSEVIER SCIENCE INC
Referencias:
Lugar: Amsterdam; Año: 2015 vol. 31 p. 570 - 570
ISSN:
0899-9007
Resumen:
ABSTRACT Objective: We studied the effects of some PUFAs plus phytomelatonin from walnuts seeds in mammary gland adenocarcinoma (M3) development. Methods: BALB/c mice were fed a semi-synthetic diet supplemented with either: 6% walnut oil and 8% walnut flour containing phytomelatonin (Walnut diet: WD); or 6% corn oil plus commercial melatonin (Melatonin diet: MD) or the control group (CD) which received only 6% of corn oil. Membrane fatty acids of tumor cells (TC) were analyzed by gas liquid chromatography, cyclooxygenases (COXs) and lipoxygenases (LOXs) derivatives and plasma melatonin by HPLC; apoptosis and tumor infiltrating lymphocytes by flow cytometry. Results: TC from MD and WD significant decreases in Linoleic acid compared to the CD group (p< 0.05). Significantly lower levels of LOXs-[13(S)-HODE] were found in TC from MD and WD than in CD (p
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