INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Unidad Ejecutora - UE
(Review) The impact of obesity on male reproduction: its biological significance.
MARTINI AC; MOLINA RI; TISSERA A; RUIZ RD; FIOL DE CUNEO M
Expert Reviews in Endocrinology and Metabolism
Año: 2013 vol. 8 p. 139 - 139
Since obesity and male subfertility have increased in parallel during the last decades, the hypothesis of an association between these two phenomena has been explored by several researchers. Although there is no consensus about this, obesity apparently impacts men´s reproductive potential by several mechanisms, like alterations on the hypothalamus-pituitary-testicular axis, modifications of spermatogenesis and semen quality and/or impairment of men´s sexual health. This review intends to summarize the underlying bases of such alterations and propose some new ones, without miscalculating their biological significance. Obesity is not rigorously related to subfertility; in addition, the existence of a genetic predisposition to obesity-linked sterility is currently under investigation. Nonetheless, the impact of obesity on male reproductive potential must be fully elucidated since the prevalence of obesity is increasing and consequently, the number of obese men with reduced fertility will rise as well.