Use of clomipramine as chemotherapy of the chronic phase of Chagas disease?.

FAURO ROMINA; LO PRESTI SILVINA; BAZÁN CAROLINA; BÁEZ ALEJANDRA; STRAUSS MARIANA; TRIQUELL FERNANDA; CREMONEZZI DAVID; SANCHEZ NEGRETE O; CAMINO, GASTÓN; PAGLINI PATRICIA; RIVAROLA WALTER

PARASITOLOGY

CAMBRIDGE UNIV PRESS

Lugar: Cambridge; Año: 2013 vol. 140 p. 917 - 927

0031-1820

Chagas infection is a major endemic disease a ff ecting Latin American countries. The persistence of Trypanosoma cruzi generates a chronic in fl ammatory reactivity that induces an immune response directed to the host?s tissues. The e ff ectiveness of the treatment in the chronic phase is still unsatisfactory due, amongst other reasons, to the collateral e ff ects of the drugs used. We investigated the e ff ect of clomipramine, a tricyclic anti-depressant that, when used as a treatment of T. cruzi- chronically infected mice, inhibits trypanothione reductase, an exclusive and vital enzyme of T. cruzi. Clomipramine improved survival (P