Structure-cytotoxicity relationships of some synthetic naphthoquinones related to lapachol

CARLA RÍOS-LUCI; LETICIA G. LEÓN; EVELYN L. BONIFAZI; GERARDO BURTON; ROSANA I. MISICO; RUBÉN P. MACHÍN; JOSÉ M. PADRÓN

Lanzarote, Canarias, España

Simposio; 4th Meeting young Cancer investigators of the Canary Islands and 2nd Meeting Young biomedical investigators of the Macaronesia; 2007

Instituto Canario de Investigacion del Cancer (ICIC)

Naphthoquinones are widespread in nature and play important physiological roles in animals and plants. Secondary metabolites bearing in their structure the 1,4 and 1,2-naphthoquinone moieties have been isolated and exhibit interesting biological activities. Structures related to lapachol are known for their various biological activities incluiding cytotoxicity to tumor cells. In the present study, we evaluated the in vitro antiproliferative activity of new lapachol derivatives, included 1,2 and 1,4-naphthoquinones.