FORCED SWIMMING REVERTS THE METABOLIC ALTERATION PRODUCED BY CHRONIC PRENATAL STRESS

BECERRA K; SOSA E; SCOPPA G; ECHEGARAY A; HUCK G; A C. LIAUDAT; RODRIGUEZ N

Congreso; XXXVII REUNIÓN CIENTIFICA ANUAL DE LA SOCIEDAD DE BIOLOGÍA DE CUYO; 2019

FORCED SWIMMING REVERTS THE METABOLIC ALTERATION PRODUCED BY CHRONIC PRENATAL STRESSBecerra K1, Sosa E1, Scoppa GI2, Echegaray NA2, Huck G3, Liaudat AC1, Rodriguez N1.1Instituto de Biotecnología Ambiental y Salud (INBIAS). Universidad Nacional de Río Cuarto (UNRC) ? Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 2Instituto Privado de Urología y Nefrología Río Cuarto. 3Universidad Nacional de Villa Mercedes.E-mail:bbecerra.kb@gmail.comNumerous evidences from animal and human studies suggest that prenatal stress is related to fetus developing to produce metabolic syndrome in adult life. Metabolic syndrome is characterized for following medical conditions: dyslipidemia, insulin resistance, glucose intolerance, hyperglycemia and increased in cellular oxidative stress. Forced swimming (FS) is a type of physical exercise, stressor that its effects depend on stimuli intensity and duration. The aim of this work was to determine the effect of prenatal immobilization (IMO) stress and postnatal FS stress on blood glucose, parameters of lipid metabolism and liver oxidative stress. For the study we used three months old male offsprings from IMO stressed mothers (EP) and offprings from no stressed mothers (CP). Half of the CP and EP animals were summited to a forced swimming section during 30 min. Before blood extraction, corticosterone (COR), glycemia, total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), triacylglycerides (TAG) and insulin levels were measured. Atherogenic index was analyzed. Thus, the livers of all animals were removed for oxidative stress (MDA levels) analysis. The animals were maintained according to the Guide for Care and Use of Laboratory Animals and the experiments were approved by the local Institutional Animal Care Committee. Results showed that FS postnatal stress increased COR levels in prenatal stress animals compared to control. IMO prenatal stress increased glucose, insulin, HDL-cholesterol, LDL-cholesterol, TAG levels and atherogenic index. Additionally, FS attenuates the alterations produced by prenatal IMO stress in all metabolic parameters evaluated while MDA concentration were higher in all stressed group compared to controls animals. In conclusion, postnatal FS reverts the effects of prenatal stress in some metabolic syndrome factors but oxidative stress could not be normalized by FS session.