EFFECTS OF PRENATAL STRESS AND POSTNATAL ACUTE FORCED SWIMMING ON SOME BIOCHEMICAL PARAMETERS OF LIVER AND SKELETAL MUSCLE

SOSA E; BECERRA K; HUCK G; A C. LIAUDAT; RODRIGUEZ N

Congreso; XXXVII REUNIÓN CIENTIFICA ANUAL DE LA SOCIEDAD DE BIOLOGÍA DE CUYO; 2019

EFFECTS OF PRENATAL STRESS AND POSTNATAL ACUTE FORCED SWIMMING ON SOME BIOCHEMICAL PARAMETERS OF LIVER AND SKELETAL MUSCLESosa E1, Becerra K1, Huck G2, Liaudat AC1, Rodriguez N1.1Instituto de Biotecnología Ambiental y Salud (INBIAS). Universidad Nacional de Río Cuarto (UNRC) ? Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). 2 Universidad Nacional de Villa Mercedes.E-mail: emi.profeef@gmail.comThe aim of this study was to analyze the physiological response of adult rats to prenatal stress and postnatal acute forced swimming on skeletal muscle and hepatic parameters. Males of three months of age were used, controls individuals (PC) and some prenatal stressed for immobilization (IMO) during pregnancy (PS). Half of the PS and PC animals were summited to postnatal forced swimming stress section during 30 min. Corticosterone (COR), glycemia and malondialdehyde (MDA) levels were studied. Our results showed that in basal conditions COR and glycemia levels are increased in PS animals. Also, after an acute exposition of forced swimming, COR significantly increase in PS group in the same way as in PC rats but with minor effects. The hepatic MDA levels, in control condition, showed a rise in PS rats compared to PC animals, being the difference maintained after forced swimming stimuli. In skeletal muscle, MDA values of PS animals were increased in basal conditions, but this effect was observed in all groups after forced swimming treatment. In conclusion, IMO prenatal stress causes a change in the regulation of the HHA axis, reflected in high basal levels of plasmatic COR and hyperglycemia. Moreover, it produces a hypersensibility to acute stressors during postnatal adult life. On the other hand, PS and forced swimming stress generate high levels of oxidative stress in the liver and skeletal muscle.