Molecular Aspects of Vitamin D Anticancer Activity

PICOTTO G; LIAUDAT AC; BOHL LP; TOLOSA DE TALAMONI NG

CANCER INVESTIGATION

TAYLOR & FRANCIS INC

Lugar: Londres; Año: 2012 vol. 30 p. 604 - 614

0735-7907

Environmentmay influence the development and prevention of cancer. Calcitriol has been associated with calcium homeostasis regulation. Many epidemiological, biochemical, and genetic studies have shown non-classic effects of vitamin D, such 10 as its involvement in the progression of different cancers. Although vitamin D induces cellular arrest, triggers apoptotic pathways, inhibits angiogenesis, and alters cellular adhesion, the precise mechanisms of its action are still not completely established. This article will present a revision 15 about themolecular aspects proposed to be involved in the anticancer action of calcitriol. Adequate levels of vitamin D to prevent cancer development will also be discussed.