Bioactive compounds isolated from the native and naturalized flora of central Argentina as potential antitumoral agents

MARIANA B. JORAY; LUCAS TRUCCO; MARÍA L. GONZÁLEZ; JOSÉ L. BOCCO; VIVIAN M. RUMJANEK; MARÍA C. CARPINELLA

RIO DE JANEIRO

Simposio; VIII Simpósio de Oncobiologia; 2014

Plants represent a valuable source of biologically active compounds. In fact, approximately one-third of the top-selling drugs have been derived from plant ingredients. Although many plant families are being studied, the plant world is far from being totally explored and this also applies to the native flora from Argentina. In this context, eighteen compounds belonging to different chemical families and showing different bioactivities were obtained in our laboratory from native and naturalized plants from Argentina: 23-methyl-6-O-desmethylauricepyrone (1), quercetin (2), 3-O-methylquercetin (3), pinocembrin (4), isoliquiritigenin (5), 7-hydroxyflavanone (6), 7,4´-dihydroxy-3´-methoxyflavanone (7), 2´,4´-dihydroxychalcone (8), (Z,Z)-5-(trideca-4,7-dienyl)-resorcinol (9), 5,2´,4´-trihydroxy-2´´,2´´-dimethylchromen-(6,7:5´´,6´´)-flavanone (10), naringenin (11), apigenin (12), scopoletin (13), ilicol (14), vanillin (15), 3-methoxy-4-hydroxycinnamaldehyde (16), pinoresinol (17) and meliartenin (18). The cytotoxic effect of these metabolites against the tumoral cells CCRF-CEM and CEM/ADR5000 (Acute Linfoblastic Leukemia); K562 and Lucena 1 (Chronic Mieloid Leukemia), A549 (Lung Cancer) and the non tumoral cell line HEK293T, was evaluated.