Neurocristopathies: New Insights 150 Years After the Neural Crest Discovery
GUILLERMO VEGA LÓPEZ; SANTIAGO CERRIZUELA; CELESTE TRÍBULO; MANUEL J. AYBAR
ACADEMIC PRESS INC ELSEVIER SCIENCE
Lugar: Amsterdam; Año: 2018 vol. 444 p. 110 - 143
The neural crest (NC) is a transient, multipotent and migratory cell population that generates an astonishingly diverse array of cell types during vertebrate development. These cells, which originate from the ectoderm in a region lateral to the neural plate in the neural fold, give rise to neurons, glia, melanocytes, chondrocytes, smooth muscle cells, odontoblasts and neuroendocrine cells, among others. Neurocristopathies (NCP) are a class of pathologies occurring in vertebrates, and especially in humans, that result from the abnormal specification, migration, differentiation or death of neural crest cells (NCCs) during embryonic development. Various pigment, skin, thyroid and hearing disorders, craniofacial and heart abnormalities, malfunctions of the digestive tract and tumors also can be considered as neurocristopathies. In this review we revisit the current classification and propose a new way to classify NCP based on the embryonic origin of tissues and recent findings of the molecular mechanisms that drive NC formation, and on the increase in the complexity of current molecular embryology.