Respiratory allergy control by probiotic fermented milk intake: a mouse model from weaning to maturity

VELEZ, EVA M. M.; WEILL, RICARDO; MALDONADO GALDEANO, CAROLINA; PERDIGÓN, GABRIELA.

Conferencia; 2nd Online International Conference on Applied Microbiology and Beneficial Microbes; 2021

Allergic disorders are an increasing disease, being the most common chronic diseases in childhood in developed and developing countries; its incidence is related to genetic factors, nutrition, hygiene measures, etc. Treatments often offer temporary improvements and do not assure long term effects. Probiotics have proven beneficial effect in human health. We have studied the effect of commercial probiotic fermented milk (PFM) in adult mice sensitized with ovalbumin (OVA), founding a beneficial effect preventing respiratory allergy development (reduction of antibodies involved in triggering allergic symptoms such as IgE, and favoring the regulation of the immune response via regulatory dendritic cells)[1, 2]. In natural conditions allergy develops early in life so we wanted to know if the effect observed in adult mice was replicated in mice when allergy is induced at weaning. At 21 days old babies were administered with PFM, some mice received the treatment continuously and some received only before being sensitized and results were compared with normal mice, sensitized mice without PFM and normal mice with PFM without OVA. PFM showed to be beneficial for sensitized mice by controlling IgE production inducing IgG, but the most notable effect was the induction of secretory IgA in lungs and maintaining a controlled stimulation of the immune cells involved in a Th1 response. Although the effect was not as strong as that reported in adult mice, PFM promoted maturation and activation of gut immune cells preserving intestinal homeostasis and lung immune response[3]