Screening of biochemical parameter in a patient with iron deficiency anemia treated with ontrarectal ozone.

JUAN J. AVERSA; PATRICIA W. STEGE

on line

Congreso; XXXIX Reunión Anual de la Sociedad de Biología de Cuyo; 2021

Anemia is a serious global health problem that affects individuals of all ages but particularly women of reproductive age. Iron deficiency anemia is one of the most common causes of anemia seen in women, with menstruation being one of the leading causes. As a trace element responsible for oxygen transport and energy balance, iron (Fe) constitutes a crucial component of haemoglobin and myoglobin particles. Iron deficiency can be treated by oral medications using different inorganic ferric or ferrous salts of iron or organic chelates such as iron proteinate or amino acid iron chelate. However, inorganic supplements such as ferrous sulphate have poor availability. Some inorganic supplements have toxic side effects mostly due to the reduction potential of these compounds, reducing ferric iron via superoxide anions. Medical O3 is used to disinfect and treat disease. Mechanism of actions is by inactivation of bacteria, viruses, fungi, yeast and protozoa, stimulation of oxygen metabolism, activation of the immune system. Medication forms in a gaseous state are somewhat unusual, and it is for this reason that special application techniques have had to be developed for the safe use of O3. Stimulation of oxygen metabolism: Ozone therapy causes an increase in the red blood cell glycolysis rate. This leads to the stimulation of 2,3-diphosphoglycerate which leads to an increase in the amount of oxygen released to the tissues. Ozone activates the Krebs cycle by enhancing oxidative carboxylation of pyruvate, stimulating production of ATP. It also causes a significant reduction in NADH and helps to oxidize cytochrome C. There is a stimulation of production of enzymes which act as free radical scavengers and cell-wall protectors: glutathione peroxidase, catalase and superoxide dismutase. Production of prostacyline, a vasodilator, is also induced by O3. The gold of the present study is finding an alternative treatment for the iron deficiency anemia which trying to avoid side effects. The biochemical preliminary parameters obtained during a short-term treatment has showed promised results reaching normal value of haemoglobin and other parameters related in the patient.