Biomarcadores de Riesgo Protrombótico en Niños con Diabetes Tipo I

ABREGU, VICTORIA; LUCIARDI, CONSTANZA; ALBORNOZ, EMILCE; MARIANI, CAROLINA; HERRERA, MATIAS; AGÜERO, TRISTAN; ÁLEMAN, MARIANO; BAZAN, MC

Congreso; Sociedad de biologia del Tucuman; 2017

Diabetes is associated with an increased risk of premature vascular disease and a subclinical inflammatory phenomenon. The objective of this study was to analyze non-HDL cholesterol (non-HDL-C) and high sensitivity C-Reactive Protein (hs-CRP) as risk markers of cardiovascular disease in children and adolescents with type 1 diabetes (T1D) according to the time of evolution of the disease and degree of glycemic control. We studied 42 diabetic children T1D and 20 healthy controls. All patients underwent a complete clinical  evaluation and hs-CRP (chemiluminiscence, Immulite 2000, Siemens, EEUU), HbA1c (DCA 2000, Siemens, Germany), fasting glycemia (FG), total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C) and triglycerides (enzymatic methods, Wiener Lab, Argentina) were determined. Low density lipoprotein-cholesterol (LDL-C) and non HDL-C were calculated. The results were expressed as median and interquartile range. The correlations were investigated with Spearman?s coefficient. Patients with T1D presented significantly higher values of glycemia, HbA1c and hs-CRP than controls. When grouping diabetics according to the duration of disease (≤ 3 or> 3 years), those with> 3 years had higher values of TC, LDL-C, non-HDL-C. When divided according to the glycemic state (HbA1c <or ≥ 7.5%), there were no significant differences between groups, except for HbA1c and FG. Non-HDL-C was correlated with age (r = 0.37, p = 0.01), duration of disease (r = 0.36, p = 0.01), and FG (r = 0.55; p = 0.0001). In conclusion, non-HDL-C would be a more sensitive cardiovascular risk marker than hs-CRP in diabetic children with more than 3 years of evolution.