Impacto de la mastitis en la muerte de células epiteliales mamarias.

DALLARD BIBIANA ELISABET

Revista Fave Ciencias Veterinarias

FACULTAD DE CIENCIAS VETERINARIAS - UNIVERSIDAD NACIONAL DEL LITORAL

Año: 2007 vol. 6 p. 20 - 29

1666-938X

Mastitis is an inflammatory reaction of the mammary gland that is usually due to a microbial infection and is recognized as the most costly disease in dairy cattle. The mammary tissue damage has been shown to be induced by either apoptosis or necrosis. These two distinct types of cell death can be distinguished by morphological, biochemical and molecular changes in dying cells. Both bacterial factors and host immune reactions contribute to epithelial tissue damage. Mastitis is characterized by an influx of somatic cells, primarily polymorphonuclear neutrophils (PMNs), into the mammary gland. The immune cells migrating into the mammary gland, breakdown of the blood-milk barrier and damage of the extracellular matrix can lead to death of epithelial cells. Understanding the biochemical and cellular changes that occur in the gland during mastitis will ultimately lead to means of manipulating mammary functions to minimize the damage from mastitis. Key words: bovine, mammary gland, mastitis, apoptosis, tissue damage.