Alginate-g-PNIPAAm copolymers with rheological properties for in situ forming scaffolds

DEMITRI, CHRISTIAN; RIZZO, CHIARA; MAFFEZZOLI, ALFONSO; LENCINA, M.M. SOLEDAD; ANDREUCETTI, NOEMÍ

Mar del Plata

Congreso; XVI Simposio Latinoamericano de Polímeros; 2018

Universidad Nacional de Mar del Plata

Focused on the biomedical applications of thermo-responsive polymers, low-doses of gamma radiation from a 60Co source were applied in a simple one-pot method to synthesize alginate-g-PNIPAAm copolymers with different percentage of grafting. Copolymers compositions were determined by TGA and their structure-property relationship were studied in terms of thermo-associative and rheological behavior in aqueous solutions. They would be attractive as specific injectable gel-forming biomaterials, acting as a temporary matrix or scaffold.