Serum periostin levels in fibrous dysplasia: Its usefulness as disease biomarker. An exploratory study

MASTAGLIA S ; GONZALEZ D ; TETZLAFF W ; BONANNO M ; GIANOTTI R ; FERNANDEZ C ; GOMEZ GLORIOSO D ; OLIVERI B

Barcelona

Congreso; World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Disease; 2020

International Osteoporosis

Fibrous dysplasia (FD) is a rare, non-hereditary bone disease caused by a somatic mutation of GNAS gene. Periostin (Postn) is a new marker, linked to bone repair processes. Objective: To assess Postn sensitivity as FD marker. Materials and Methods: An exploratory case-control study was led, with 15 FD patients, paired by age and gender with healthy subjects (controls). Postn serum levels were gauged in FD patients and controls, also according to clinical manifestation. In the same assay, with serum samples stored at -80°C, Postn was measured by the ELISA method (Sigma-Aldrich; St. Louis, USA), [coefficient of variation (%CV) intra-assay