SLPI and vitamin D: indirect markers of the immune system in the elderly?

OLIVERI B; AMBROSSI N ; BONANNO M; MASTAGLIA S ; CHULUYAN E

Congreso; Cuarto Congreso Argentino de Osteología y Metabolismo Mineral; 2021

Vitamin D (VD) has immunomodulatory properties. Immunosenescence and VD deficiency coexist in the elderly, and this could affect immune response mediators such as secretory leukocyteprotease inhibitor (SLPI), a leukocyte inhibitor with antimicrobial and anti-inflammatory activity and promoter of tolerogenic response. Objective: To evaluate circulating SLPI levels as a marker of tolerogenic immune profile, and their association with serum 25-hydroxyvitamin D (25OHD) levels in the elderly. Materials and Methods: The study comprised 36 women aged (mean SD) 70.7 6.9 years. Exclusion criteria: Infectious diseases (within 3 months prior to enrollment), autoimmune diseases, creatinine clearance (CrCl)