CONICET | Buscador de Institutos y Recursos Humanos

Carvacrol (CAR) is a natural phenolic compound, recognized for its antioxidant and neuroprotective properties. Although, it presents drawbacks such as its limited aqueous solubility, high volatility and its rapid degradation. One possible strategy to overcome these drawbacks is to incorporate CAR into nanoparticulate liquid systems.The present work reports the synthesis and physicochemical characterization of the nanoparticulate systems obtained from the mixture of Phytantriol (PHY) and glycerol monooleate (GMO) in different proportions 25:75, 55:45, 70:30 respectively. These systems were characterized through particle size, polydispersity (PDI), potential Z, and pH. The releases of the nanoparticle systems loaded with CAR resulted in a sustained release of the compound for 24 hours, obtaining release percentages of 4% (70:30), 15% (55:45), 20% (25:75) for the formulations, in comparison to the CAR which was 100%. Its release was slower when proportions of PHY was increased in the formulation. In conclusion, the results demonstrated that nanoparticulate liquid systems for topical ocular delivery of CAR are of interest for further research.Keywords: carvacrol, nanoparticle, lipids.FundingThis research was funded by Roche Collaborative Research Fellowship. Given by ARVO: The Asociación for Research in Vision Ophtalmology. USA. 2019. -Potential neuroprotective effect of antioxidants included in innovative pharmaceutical formulations. AcknowledgmentsThe authors wish to acknowledge the assistance of the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) and Universidad Nacional de Córdoba, for having provided support and facilities for this investigation.Conflicts of Interest ?The authors declare no conflict of interest?.

enviar mensaje